A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents.
نویسندگان
چکیده
A novel, simple, and efficient method for the synthesis of 4,5-dihydropyrazole derivatives has been developed. The reaction proceeded through the base-induced isomerization of easily accessible propargyl alcohols followed by cyclization of α,β-unsaturated hydrazones. Furthermore, selected compounds 3ab and 3ac exhibited good activities against Bel-7404 (human hepatoma cancer), HepG2 (human liver cancer), NCI-H460 (human lung cancer) and SKOV3 (human ovarian cancer) cell lines with IC50 in the range of 22-46 μmol L(-1).
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 13 شماره
صفحات -
تاریخ انتشار 2014